产品货号：
Z27763
中文名称：
TFEB抗体
英文名称：
Anti-TFEB Antibody
产品规格：
100μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-TFEB Antibody |
| 指标别名 | AlphaTFEB;bHLHe35;TCFEB;TFEB;transcription factor EB |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse |
| 应用范围 | WB,IHC,ELISA |
| 基因名称 | TFEB |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | Synthesized peptide derived from human TFEB |
| 计算分子量 | 53KD |
| 成分 | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| 纯化方式 | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | -20℃可保存1年，短期保存或频繁使用请置于4℃，可保存一个月，避免反复冻融。 |
| 背景资料 | Transcription factor EB is a protein that in humans is encoded by the TFEB gene.TFEB is a master gene for lysosomal biogenesis.It encodes a transcription factor that coordinates expression of lysosomal hydrolases,membrane proteins and genes involved in autophagy.Upon nutrient depletion and under aberrant lysosomal storage conditions such as in lysosomal storage diseases,TFEB translocates from the cytoplasm to the nucleus,resulting in the activation of its target genes.TFEB overexpression in cultured cells induces lysosomal biogenesis,exocytosis and autophagy.Viral-mediated TFEB overexpression in cellular and mouse models of lysosomal storage disorders and in common neurodegenerative diseases such as Huntington,Parkinson and Alzheimer diseases,resulted in intracellular clearance of accumulating molecules and rescue of disease phenotypes.TFEB is activated by PGC1-alpha and promotes reduction of htt aggregation and neurotoxicity in a mouse model of Huntington disease.TFEB overexpression has been found in patients with renal cell carcinoma and pancreatic cancer and was shown to promote tumorogenesis via induction of varius oncogenic signals. |
| Uniprot ID | P19484 |
| 基因名全称 | Transcription factor EB |
| 蛋白名全称 | Transcription factor EB |
| 推荐稀释比 | WB 1:500～1:2000 IHC 1:100～1:300 ELISA 1:20000 |
相关搜索：TFEB抗体，TFEB多抗，Anti-TFEB Antibody